Towards the Unified Principles for Level 5 Autonomous Vehicles

The rapid advance of autonomous vehicles (AVs) has motivated new perspectives and potential challenges for existing modes of transportation. Currently, driving assistance systems of Level 3 and below have been widely produced, and several applications of Level 4 systems to specific situations have also been gradually developed. By improving the automation level and vehicle intelligence, these systems can be further advanced towards fully autonomous driving. However, general development concepts for Level 5 AVs remain unclear, and the existing methods employed in the development processes of Levels 0–4 have been mainly based on task-driven function development related to specific scenarios. Therefore, it is difficult to identify the problems encountered by high-level AVs. The essential logical and physical mechanisms of vehicles have hindered further progression towards Level 5 systems. By exploring the physical mechanisms behind high-level autonomous driving systems and analyzing the essence of driving, we put forward a coordinated and balanced framework based on the brain–cerebellum–organ concept through reasoning and deduction. Based on a mixed mode relying on the crow inference and parrot imitation approach, we explore the research paradigm of autonomous learning and prior knowledge to realize the characteristics of self-learning, self-adaptation, and self-transcendence for AVs. From a systematic, unified, and balanced point of view and based on least action principles and unified safety field concepts, we aim to provide a novel research concept and develop an effective approach for the research and development of high-level AVs, specifically at Level 5.     

基于网络药理学和文献探讨异喹啉类生物碱抗肝癌研究进展

探索五种异喹啉类生物碱抗肝癌的作用机制。借助TCMSP、String、venny数据库与WebGestalt在线分析软件获取靶点并进行蛋白互作网络（PPI）、基因本体（GO）、基因相互作用（KEGG）功能富集分析，利用Cytoscape软件构建网络。同时查阅文献并进行归纳、整理和分析得到小檗碱型中的小檗碱、双苄基类生物碱的粉防己碱、苯菲啶喹啉类的血根碱、吗啡烷类中的青藤碱和吡咯菲里啶中的石蒜碱等几种常见的生物碱，根据结构作用机制阐述每一类代表性异喹啉类生物碱治疗肝癌的潜力及抗肝癌作用机制。五个活性成分共筛选得到52个作用靶标如p53（抑癌基因）、NCOA2（核受体共激活剂2）、IL-2（白介素2），主要涉及钙离子信号通路、雌激素受体信号通路和PI3K/Akt信号传导途径等通路。通过网络药理学和文献收集证实异喹啉类生物碱可能参与调控PI3K-Akt通路等，可以通过多靶点、多通路对肝癌产生治疗作用，为进一步研究异喹啉类生物碱抗肝癌的临床研究提供参考和依据。     

Antibacterial activity and action target of phenyllactic acid against Staphylococcus aureus and its application in skim milk and cheese

Phenyllactic acid (PLA) has been demonstrated to possess antibacterial activity and capacity to prolong food shelf life. However, studies on the performance of PLA in inhibiting Staphylococcus aureus and its effectiveness when applied to dairy products are largely lacking. Here, antibacterial activity (planktonic and biofilm states) of PLA against S. aureus CICC10145 (S. aureus_45) were investigated. The results showed that PLA inhibited growth of S. aureus_45 and formation of S. aureus_45 biofilm. Next, the antibacterial action target of PLA was uncovered from both physiological and phenotypic perspectives. The results showed that PLA decreased cell metabolic activity and cell viability, damaged cell membrane integrity, triggered leakage of intracellular contents (DNA, proteins, and ATP), and caused oxidative stress damage and morphological deformation of S. aureus_45. In practical application, the antibacterial activity of PLA against S. aureus_45 cells was further confirmed in skim milk and cheese as dairy food models, and the antibacterial effects can be adequately maintained during storage for 21 d, at least at 4°C. These findings suggested that PLA could be a potential candidate for controlling S. aureus outgrowth in dairy foods.     

采动区建筑物附加地基反力变化规律研究

为了研究采动区建筑物附加地基反力的变化规律，采用采动区建筑物地基、基础和结构协同作用力学模型，研究了建筑物位于采动区不同位置时附加地基反力的分布变化规律，指出地表曲率变形值是控制附加地基反力大小及分布形态的主导因素；并研究了建筑物长度、弹性模量、地基系数、开采厚度、建筑物高度等各种因素对建筑物附加地基反力的影响规律，同时建立了附加地基反力最大值与各影响因素之间的关系式.     

异型柱框架、框-剪结构在高层建筑中的应用

结合一住宅小区的结构设计．对异型柱框架、框一剪结构的破坏机理、计算理论和结构构造进行了探讨，供设计同仁参考。     

岩石断裂演化过程元胞自动机模型的研究

提出了一种研究岩石断裂演化过程的元胞自动机模型。通过大量模拟发现，岩石断裂演化过程是岩石内部微裂隙萌生、扩展、聚集和贯通的的过程，大量微裂隙的集体行为具有特定的规律。在岩石断裂演化过程中，微裂隙的空间分布是一个分级维形态的生长过程，岩石内完整岩石微元的空间分布是一个降维过程。岩石断裂隙化过程是一个确定性和随机性统一的过程，其中的分形物理机制是研究的关键。     

水平定向钻机卡瓦的作用机理研究与改进

将水平定向钻机的卡瓦分为整体式卡瓦与组合式卡瓦2种。计算得到它们与钻杆表面的作用机理分别为表面接触式和嵌入式。初步确定了卡瓦与钻杆之间的摩擦系数。最后,针对卡瓦打滑和伤害钻杆的问题,设计出了菱形齿面卡瓦和嵌入合金颗粒的卡瓦。     

企业素质-人才、技术、管理的研究(之一)

企业素质包括管理、技术和人才3个方面，通过实例，论述了企业素质决定经营活动成果的质量，决定企业进入市场的能力。     

改性粉煤灰填充橡胶的研究

研究了改性粉煤灰填充橡胶物理机械性能 ,结果表明 :经过改性处理的粉煤灰对橡胶具有良好的补强作用 ,可以完全替代CaCO3 、部分替代炭黑     

不同设计基准期地震动参数取值

提出了不同的设计基准期所对应的地震烈度及地震动参数的计算方法，并通过工程实例，对不同设计基准期的地震动参数进行了设计计算。